Keratinocytes
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Keratinocytes

Keratinocytes: Key Players in Skin Health and Research

Definition and Location
Keratinocytes are the primary cell type found in the epidermis, the outermost layer of the skin. They account for approximately 90% of epidermal cells and form a protective barrier against environmental damage, pathogens, and water loss.


Differentiation of Keratinocytes
Keratinocytes originate in the basal layer of the epidermis and undergo a multi-step differentiation process as they migrate to the surface. This process results in the formation of the stratum corneum, a tough, keratinized layer that provides structural integrity and resilience to the skin.


Function
Keratinocytes serve as a physical barrier and play a vital role in immune response, producing cytokines and antimicrobial peptides to defend against infections. They also regulate skin hydration through the production of natural moisturizing factors.


Applications
In research and clinical settings, keratinocytes are widely used for studying skin biology, wound healing, inflammatory diseases, and skin-related drug testing. Their importance in cosmetic and pharmaceutical applications makes them a valuable tool for innovation in dermatology.


Interactions with Other Cells in the Skin
Keratinocytes interact with melanocytes to influence pigmentation, Langerhans cells to mediate immune responses, and fibroblasts in the dermis to coordinate extracellular matrix production. These interactions are critical for maintaining overall skin health and functionality.


Role in Wound Healing and Inflammation
During wound healing, keratinocytes migrate to close the wound and proliferate to restore the epidermal layer. They secrete growth factors and cytokines to regulate inflammation and facilitate tissue repair, making them essential for skin regeneration.


Keratinocytes by PromoCell
PromoCell offers high-quality human primary keratinocytes derived from various donors and anatomical locations. These cells are ideal for applications in skin biology research, drug development, and regenerative medicine. PromoCell’s keratinocytes are meticulously cultured to ensure consistency and reliability, empowering researchers to make breakthroughs in skin science.



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Biofda biotechnology  is a leading manufacturer of  polypeptide APIs instruments and Skincare peptide components in China. 
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